E-ISSN 2577-5669
 

Original Research 


Detection of missense and frame shift mutations in envelope proteins using molecular phylogenetic SARS-COV-2

*Noor R Abady, zaytoon A alkhafaji, Ali saleh Baay.

Abstract
The envelope (E) protein, which is 76–109 amino acids long, is a structural viroporin identified in coronaviruses. On March 1, 2020, ten distinct E-proteins were selected out of a total of 50 at the general Health laboratory (Babil), and the partial E gene of SARS-CoV-2 genomes was sequenced and recoded in the GenBank with accession number MW827729, MW827730, MW827731, MW827732, MW827733, MW827734, MW827735,MW827736, MW827737, MW827738. The study looked for missense and frame shift mutations in the envelope proteins of different Covid 19 patients to determine the lineage of the direct envelope protein (SARS-CoV-2). A phylogenetic analysis of envelope proteins, which looks at sequence homology and amino acid conservation, provides even more evidence to the evolutionary origin. Frame-shift mutations were found in both the N and C terminals of the 10 known partial sequences of human SARS- COV2. genomes.

Key words: SARS-COV-2, E gene, Frame shift , missense mutation


 
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How to Cite this Article
Pubmed Style

NRA, zAa, Baay As. Detection of missense and frame shift mutations in envelope proteins using molecular phylogenetic SARS-COV-2. J Complement Med Res. 2022; 13(1): 92-97. doi:10.5455/jcmr.2022.13.01.17


Web Style

NRA, zAa, Baay As. Detection of missense and frame shift mutations in envelope proteins using molecular phylogenetic SARS-COV-2. https://www.jocmr.com/?mno=40152 [Access: June 30, 2022]. doi:10.5455/jcmr.2022.13.01.17


AMA (American Medical Association) Style

NRA, zAa, Baay As. Detection of missense and frame shift mutations in envelope proteins using molecular phylogenetic SARS-COV-2. J Complement Med Res. 2022; 13(1): 92-97. doi:10.5455/jcmr.2022.13.01.17



Vancouver/ICMJE Style

NRA, zAa, Baay As. Detection of missense and frame shift mutations in envelope proteins using molecular phylogenetic SARS-COV-2. J Complement Med Res. (2022), [cited June 30, 2022]; 13(1): 92-97. doi:10.5455/jcmr.2022.13.01.17



Harvard Style

, N. R. A., , . z. A. a. & Baay, . A. s. (2022) Detection of missense and frame shift mutations in envelope proteins using molecular phylogenetic SARS-COV-2. J Complement Med Res, 13 (1), 92-97. doi:10.5455/jcmr.2022.13.01.17



Turabian Style

, Noor R Abady, zaytoon A alkhafaji, and Ali saleh Baay. 2022. Detection of missense and frame shift mutations in envelope proteins using molecular phylogenetic SARS-COV-2. Journal of Complementary Medicine Research, 13 (1), 92-97. doi:10.5455/jcmr.2022.13.01.17



Chicago Style

, Noor R Abady, zaytoon A alkhafaji, and Ali saleh Baay. "Detection of missense and frame shift mutations in envelope proteins using molecular phylogenetic SARS-COV-2." Journal of Complementary Medicine Research 13 (2022), 92-97. doi:10.5455/jcmr.2022.13.01.17



MLA (The Modern Language Association) Style

, Noor R Abady, zaytoon A alkhafaji, and Ali saleh Baay. "Detection of missense and frame shift mutations in envelope proteins using molecular phylogenetic SARS-COV-2." Journal of Complementary Medicine Research 13.1 (2022), 92-97. Print. doi:10.5455/jcmr.2022.13.01.17



APA (American Psychological Association) Style

, N. R. A., , . z. A. a. & Baay, . A. s. (2022) Detection of missense and frame shift mutations in envelope proteins using molecular phylogenetic SARS-COV-2. Journal of Complementary Medicine Research, 13 (1), 92-97. doi:10.5455/jcmr.2022.13.01.17