E-ISSN 2577-5669
 

Original Research 


Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats

Abeer Ibrahim Abd EL-Fattah, Saana Ahmed Ali:, Hanan Farouk Aly, Howaida Ibrahim Abd-Alla, Nagwa M Shalaby, Marwa Hamed Saleh.

Abstract
Achillea fragrantissima is a perennial herb used by Arabic Bedouin for the treatment of several pathologies. Type 2 diabetes mellitus (T2DM) is a metabolic disorder that is usually associated with hyperlipidemia into what is nowadays known as the metabolic syndrome epidemic. Aim: is to evaluate the effects of alcoholic and ethyl acetate extracts of A. fragrantissima in metabolically manipulated T2DM rats. Materials and Methods: Induction of T2DM in rats was through high–fat diet (HFD) for twelve consecutive weeks followed by a single injection of streptozotocin (STZ). The activities of both A. fragrantissima extracts were assessed in comparison with glibenclamide and fenofibrate as reference drugs. Results: Elevated blood glucose levels, serum lipid profile, liver functions and kidney functions witnessed a significant reduction by treatment with the extracts. Meanwhile, Oxidative stress markers (MDA, GPx and SOD), pro-inflammatory biomarkers (TNF-α and IL-6 )and adhesion molecules (ICAM-1 and VCAM-1) assessments recorded significant improvement after treatment with A. fragrantissima extracts.The results were also associated with improvement in histopathological examination of pancreas, liver and kidney tissues. The total polyphenolic and flavonoid contents were determined spectrophotometrically. Seven phenolic compounds were isolated and identified in the ethyl acetate extract’s fractions; three flavonoid glycosides, four flavonoid aglycones and a triterpene. Conclusions: The current study suggests that A. fragrantissima extract might be considered as a promising natural supplement for management of T2DM manifestations.

Key words: Achillea fragrantissima, Adhesion molecules, Antioxidant, Pro-inflammatory cytokines, T2DM, Chemical composition


 
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Pubmed Style

EL-Fattah AIA, Ali: SA, Aly HF, Abd-Alla HI, Shalaby NM, Saleh MH. Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats. J Complement Med Res. 2018; 7(2): 115-130. doi:10.5455/jcmr.20180121122758


Web Style

EL-Fattah AIA, Ali: SA, Aly HF, Abd-Alla HI, Shalaby NM, Saleh MH. Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats. http://www.jocmr.com/?mno=287474 [Access: September 19, 2018]. doi:10.5455/jcmr.20180121122758


AMA (American Medical Association) Style

EL-Fattah AIA, Ali: SA, Aly HF, Abd-Alla HI, Shalaby NM, Saleh MH. Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats. J Complement Med Res. 2018; 7(2): 115-130. doi:10.5455/jcmr.20180121122758



Vancouver/ICMJE Style

EL-Fattah AIA, Ali: SA, Aly HF, Abd-Alla HI, Shalaby NM, Saleh MH. Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats. J Complement Med Res. (2018), [cited September 19, 2018]; 7(2): 115-130. doi:10.5455/jcmr.20180121122758



Harvard Style

EL-Fattah, A. I. A., Ali:, S. A., Aly, H. F., Abd-Alla, H. I., Shalaby, N. M. & Saleh, M. H. (2018) Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats. J Complement Med Res, 7 (2), 115-130. doi:10.5455/jcmr.20180121122758



Turabian Style

EL-Fattah, Abeer Ibrahim Abd, Saana Ahmed Ali:, Hanan Farouk Aly, Howaida Ibrahim Abd-Alla, Nagwa M Shalaby, and Marwa Hamed Saleh. 2018. Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats. Journal of Complementary Medicine Research, 7 (2), 115-130. doi:10.5455/jcmr.20180121122758



Chicago Style

EL-Fattah, Abeer Ibrahim Abd, Saana Ahmed Ali:, Hanan Farouk Aly, Howaida Ibrahim Abd-Alla, Nagwa M Shalaby, and Marwa Hamed Saleh. "Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats." Journal of Complementary Medicine Research 7 (2018), 115-130. doi:10.5455/jcmr.20180121122758



MLA (The Modern Language Association) Style

EL-Fattah, Abeer Ibrahim Abd, Saana Ahmed Ali:, Hanan Farouk Aly, Howaida Ibrahim Abd-Alla, Nagwa M Shalaby, and Marwa Hamed Saleh. "Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats." Journal of Complementary Medicine Research 7.2 (2018), 115-130. Print. doi:10.5455/jcmr.20180121122758



APA (American Psychological Association) Style

EL-Fattah, A. I. A., Ali:, S. A., Aly, H. F., Abd-Alla, H. I., Shalaby, N. M. & Saleh, M. H. (2018) Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats. Journal of Complementary Medicine Research, 7 (2), 115-130. doi:10.5455/jcmr.20180121122758





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