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Original Research 


Anti-nociceptive and anti- inflammatory activities of the methanol extract of Waltheria americana leaf in experimental animals.

Idowu Olumorin Owemidu, Mujeedat Adebukola Olubori, Oluwaseun Samuel Faborode, Oluwatobi Stephen Oloyede, Samuel Adetunji Onasanwo.

Abstract
ABSTRACT
Background: Waltheria americana has been used in African folklore for the treatment of minor and complicated ailments like pain, fever and rheumatism. Aim: To investigate the analgesic and anti-inflammatory potentials of Waltheria americana, and its possible mechanism of action in Swiss mice and Wistar rats, respectively. Materials and Methods: Methanol extract of Waltheria americana leaf was evaluated for anti-nociceptive activities (using tail flick, formalin-induced paw licking and acetic acid-induced writhing tests in mice), and possible mechanisms of action using Atropine (5mg/kg i.p), prazosin (1mg/kg p.o), glibenclamide (8mg/kg p.o), propranolol (40mg/kg p.o), naloxone (2mg/kg i.p) nifedipine (10 mg/kg p.o) using acetic acid and tail-flick models of analgesia. The anti-inflammatory effect was evaluated in carrageenan-induced paw edema and cotton pellet-induced granuloma tests. Results: Acute toxicity revealed no mortality in the mice up to a dose of 2000mg/kg. The phytochemistry revealed the presence of alkaloids, flavonoids, saponins and terpenoids. The extract (100 or 200 mg/kg) produced inhibition (p<0.05) both in the formalin-induced paw licking and acetic acid-induced writhing tests. In the thermal test, the extract (200mg/kg) significantly increased the withdrawal latency. There were reversal of the analgesic effect of the extract with the cholinergic and opioidergic blockers that significantly produced changes in the analgesic effects of the extract. The extract produced dose related inhibition of cotton pellet induced granuloma in rats and carrageenan induced paw edema in rats. Conclusion: The extract produced anti-inflammatory potentials, and anti-nociception through mechanisms that may dependent on the cholinergic and opioidergic system.

Key words: Anti-nociception, Waltheria americana, Nifedipine, Prazosin, Atropine, anti-inflammatory


 
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How to Cite this Article
Pubmed Style

Idowu Olumorin Owemidu, Mujeedat Adebukola Olubori, Oluwaseun Samuel Faborode, Oluwatobi Stephen Oloyede, Samuel Adetunji Onasanwo. Anti-nociceptive and anti- inflammatory activities of the methanol extract of Waltheria americana leaf in experimental animals.. J Complement Med Res. 2018; 9(2): 47-54. doi:10.5455/jcmr.20180118112751


Web Style

Idowu Olumorin Owemidu, Mujeedat Adebukola Olubori, Oluwaseun Samuel Faborode, Oluwatobi Stephen Oloyede, Samuel Adetunji Onasanwo. Anti-nociceptive and anti- inflammatory activities of the methanol extract of Waltheria americana leaf in experimental animals.. http://www.jocmr.com/?mno=287254 [Access: February 15, 2020]. doi:10.5455/jcmr.20180118112751


AMA (American Medical Association) Style

Idowu Olumorin Owemidu, Mujeedat Adebukola Olubori, Oluwaseun Samuel Faborode, Oluwatobi Stephen Oloyede, Samuel Adetunji Onasanwo. Anti-nociceptive and anti- inflammatory activities of the methanol extract of Waltheria americana leaf in experimental animals.. J Complement Med Res. 2018; 9(2): 47-54. doi:10.5455/jcmr.20180118112751



Vancouver/ICMJE Style

Idowu Olumorin Owemidu, Mujeedat Adebukola Olubori, Oluwaseun Samuel Faborode, Oluwatobi Stephen Oloyede, Samuel Adetunji Onasanwo. Anti-nociceptive and anti- inflammatory activities of the methanol extract of Waltheria americana leaf in experimental animals.. J Complement Med Res. (2018), [cited February 15, 2020]; 9(2): 47-54. doi:10.5455/jcmr.20180118112751



Harvard Style

Idowu Olumorin Owemidu, Mujeedat Adebukola Olubori, Oluwaseun Samuel Faborode, Oluwatobi Stephen Oloyede, Samuel Adetunji Onasanwo (2018) Anti-nociceptive and anti- inflammatory activities of the methanol extract of Waltheria americana leaf in experimental animals.. J Complement Med Res, 9 (2), 47-54. doi:10.5455/jcmr.20180118112751



Turabian Style

Idowu Olumorin Owemidu, Mujeedat Adebukola Olubori, Oluwaseun Samuel Faborode, Oluwatobi Stephen Oloyede, Samuel Adetunji Onasanwo. 2018. Anti-nociceptive and anti- inflammatory activities of the methanol extract of Waltheria americana leaf in experimental animals.. Journal of Complementary Medicine Research, 9 (2), 47-54. doi:10.5455/jcmr.20180118112751



Chicago Style

Idowu Olumorin Owemidu, Mujeedat Adebukola Olubori, Oluwaseun Samuel Faborode, Oluwatobi Stephen Oloyede, Samuel Adetunji Onasanwo. "Anti-nociceptive and anti- inflammatory activities of the methanol extract of Waltheria americana leaf in experimental animals.." Journal of Complementary Medicine Research 9 (2018), 47-54. doi:10.5455/jcmr.20180118112751



MLA (The Modern Language Association) Style

Idowu Olumorin Owemidu, Mujeedat Adebukola Olubori, Oluwaseun Samuel Faborode, Oluwatobi Stephen Oloyede, Samuel Adetunji Onasanwo. "Anti-nociceptive and anti- inflammatory activities of the methanol extract of Waltheria americana leaf in experimental animals.." Journal of Complementary Medicine Research 9.2 (2018), 47-54. Print. doi:10.5455/jcmr.20180118112751



APA (American Psychological Association) Style

Idowu Olumorin Owemidu, Mujeedat Adebukola Olubori, Oluwaseun Samuel Faborode, Oluwatobi Stephen Oloyede, Samuel Adetunji Onasanwo (2018) Anti-nociceptive and anti- inflammatory activities of the methanol extract of Waltheria americana leaf in experimental animals.. Journal of Complementary Medicine Research, 9 (2), 47-54. doi:10.5455/jcmr.20180118112751