E-ISSN 2577-5669
 

Original Research 


Effects of aqueous leaf infusion of Pterocarpus santalinoides DC on the serum lipid profile of guinea pigs (Carvia porcellus)

Thelma Ebele Ihedioha, Victor Nnaemeka Okechukwu, John Ikechukwu Ihedioha.

Abstract
AIM: This study investigated the effects of aqueous leaf infusion of Pterocarpus santalinoides DC on serum lipid profile (SLP) of guinea pigs (GPs).
METHODS: Fresh leaves of Pterocarpus. santalinoides were collected in February 2015. Aqueous leaf infusion was freshly prepared daily by soaking dried ground P. santalinoides leaf in hot water for 10 minutes. Twenty female GPs were randomly assigned into 4 groups (A – D) of 5 GPs each as follows: Group A – distilled water placebo per os (control), groups B, C and D – 1.5, 3.0 and 4.5 g/kg body weight (bw) of ground P. santalinoides leaf in 600ml of hot and cooled water per os respectively. Treatment was carried out for 28 days. Assay of SLP was done on days 0 (before treatment), and on days 14 and 28 of treatment following standard procedures.
RESULTS: The mean serum high density lipoprotein cholesterol (HDLC) of groups B, C and D rose to almost double its baseline values and was significantly (p < 0.05) higher than that of group A on day 28, while the mean serum low density lipoprotein cholesterol (LDLC) of group D was significantly lower (p<0.05) than those of other groups. The mean serum triglyceride and very low density lipoprotein cholesterol (VLDLC) of groups B and C were significantly lower (p < 0.05) than that of group A at day 14 and 28 of treatment.
CONCLUSION: The outcome of this study gives credence to the traditional use of this plant in the treatment of heart diseases.

Key words: Key words: Pterocarpus santalinoides, aqueous leaf infusion, serum lipid profile, guinea pigs.


 
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Pubmed Style

Thelma Ebele Ihedioha, Victor Nnaemeka Okechukwu, John Ikechukwu Ihedioha. Effects of aqueous leaf infusion of Pterocarpus santalinoides DC on the serum lipid profile of guinea pigs (Carvia porcellus). J Complement Med Res. 2018; 7(2): 154-160. doi:10.5455/jcmr.20180113015556


Web Style

Thelma Ebele Ihedioha, Victor Nnaemeka Okechukwu, John Ikechukwu Ihedioha. Effects of aqueous leaf infusion of Pterocarpus santalinoides DC on the serum lipid profile of guinea pigs (Carvia porcellus). http://www.jocmr.com/?mno=284761 [Access: December 12, 2018]. doi:10.5455/jcmr.20180113015556


AMA (American Medical Association) Style

Thelma Ebele Ihedioha, Victor Nnaemeka Okechukwu, John Ikechukwu Ihedioha. Effects of aqueous leaf infusion of Pterocarpus santalinoides DC on the serum lipid profile of guinea pigs (Carvia porcellus). J Complement Med Res. 2018; 7(2): 154-160. doi:10.5455/jcmr.20180113015556



Vancouver/ICMJE Style

Thelma Ebele Ihedioha, Victor Nnaemeka Okechukwu, John Ikechukwu Ihedioha. Effects of aqueous leaf infusion of Pterocarpus santalinoides DC on the serum lipid profile of guinea pigs (Carvia porcellus). J Complement Med Res. (2018), [cited December 12, 2018]; 7(2): 154-160. doi:10.5455/jcmr.20180113015556



Harvard Style

Thelma Ebele Ihedioha, Victor Nnaemeka Okechukwu, John Ikechukwu Ihedioha (2018) Effects of aqueous leaf infusion of Pterocarpus santalinoides DC on the serum lipid profile of guinea pigs (Carvia porcellus). J Complement Med Res, 7 (2), 154-160. doi:10.5455/jcmr.20180113015556



Turabian Style

Thelma Ebele Ihedioha, Victor Nnaemeka Okechukwu, John Ikechukwu Ihedioha. 2018. Effects of aqueous leaf infusion of Pterocarpus santalinoides DC on the serum lipid profile of guinea pigs (Carvia porcellus). Journal of Complementary Medicine Research, 7 (2), 154-160. doi:10.5455/jcmr.20180113015556



Chicago Style

Thelma Ebele Ihedioha, Victor Nnaemeka Okechukwu, John Ikechukwu Ihedioha. "Effects of aqueous leaf infusion of Pterocarpus santalinoides DC on the serum lipid profile of guinea pigs (Carvia porcellus)." Journal of Complementary Medicine Research 7 (2018), 154-160. doi:10.5455/jcmr.20180113015556



MLA (The Modern Language Association) Style

Thelma Ebele Ihedioha, Victor Nnaemeka Okechukwu, John Ikechukwu Ihedioha. "Effects of aqueous leaf infusion of Pterocarpus santalinoides DC on the serum lipid profile of guinea pigs (Carvia porcellus)." Journal of Complementary Medicine Research 7.2 (2018), 154-160. Print. doi:10.5455/jcmr.20180113015556



APA (American Psychological Association) Style

Thelma Ebele Ihedioha, Victor Nnaemeka Okechukwu, John Ikechukwu Ihedioha (2018) Effects of aqueous leaf infusion of Pterocarpus santalinoides DC on the serum lipid profile of guinea pigs (Carvia porcellus). Journal of Complementary Medicine Research, 7 (2), 154-160. doi:10.5455/jcmr.20180113015556





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