E-ISSN 2577-5669
 

Original Research 


Comparative study of Annona senegalensis (Annonaceae) and Hallea ledermannii (Rubiacaceae) effects on glycemia in rats

Goore Guy Charles Gole NANTI, Semi Anthelme NENE BI, Ouga Stanislas ZAHOUI, Flavien TRAORE.

Abstract
Aim : In order to promote African traditional pharmacopoeia, studies have been undertaken to evaluate the effects of aqueous extracts of Annona senegalensis (Annonaceae) (EAAs) and Hallea ledermannii (Rubiaceae) (EAHl) in white rats of Wistar strain. Methods: A phytochemical screening and a toxicological study according to the Organisation for Economic Co-operation and Development (OECD) guidelines 423 were carried out. Pharmacological effects on blood glucose were evaluated. The different treatments were performed orally. Results: The aqueous extracts of EAAs and EAHl, respectively at the maximum doses of 3000 and 5000 mg / kg bw, did not cause death in rats. Phytochemical screening revealed the presence of polyphenols, flavonoids and quinonic compounds in both extracts. This study showed that in addition to the common compounds, the Annona senegalensis extract contained sterols, polyterpenes, catechic tannins and alkaloids, while that of Hallea ledermannii showed the existence of saponosides. Annona senegalensis (100 mg/kg bw) and Hallea ledermannii (200 mg/kg bw), provoked more hypoglycemia respectevely of 40 % and 35.34 % in rats. EAAS (27.78 % vs 25.41 %) showed better anti-hyperglycemic effect in pretreated rats while EAHl (40.30 % vs 29.37 %), provoked more anti-hyperglycemic activity in post-treated animals. Conclusion: The effects of EAAs and EAHI on blood glucose value, may be related to the presence of chemical compounds such as flavonoids and saponosides highlighted in phytochemical study. These compounds recall those of certain insulin-secreting agents and justify their use in traditional medicine.

Key words: Annona sengalensis, Hallea ledermannii, Glibenclamide, hypoglycemia, anti-hyperglycemia, rat.


 
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Pubmed Style

NANTI GGCG, BI SAN, ZAHOUI OS, TRAORE F. Comparative study of Annona senegalensis (Annonaceae) and Hallea ledermannii (Rubiacaceae) effects on glycemia in rats. J Complement Med Res. 2018; 7(1): 1-7. doi:10.5455/jice.20170909091946


Web Style

NANTI GGCG, BI SAN, ZAHOUI OS, TRAORE F. Comparative study of Annona senegalensis (Annonaceae) and Hallea ledermannii (Rubiacaceae) effects on glycemia in rats. http://www.jocmr.com/?mno=277402 [Access: April 23, 2018]. doi:10.5455/jice.20170909091946


AMA (American Medical Association) Style

NANTI GGCG, BI SAN, ZAHOUI OS, TRAORE F. Comparative study of Annona senegalensis (Annonaceae) and Hallea ledermannii (Rubiacaceae) effects on glycemia in rats. J Complement Med Res. 2018; 7(1): 1-7. doi:10.5455/jice.20170909091946



Vancouver/ICMJE Style

NANTI GGCG, BI SAN, ZAHOUI OS, TRAORE F. Comparative study of Annona senegalensis (Annonaceae) and Hallea ledermannii (Rubiacaceae) effects on glycemia in rats. J Complement Med Res. (2018), [cited April 23, 2018]; 7(1): 1-7. doi:10.5455/jice.20170909091946



Harvard Style

NANTI, G. G. C. G., BI, S. A. N., ZAHOUI, O. S. & TRAORE, F. (2018) Comparative study of Annona senegalensis (Annonaceae) and Hallea ledermannii (Rubiacaceae) effects on glycemia in rats. J Complement Med Res, 7 (1), 1-7. doi:10.5455/jice.20170909091946



Turabian Style

NANTI, Goore Guy Charles Gole, Semi Anthelme NENE BI, Ouga Stanislas ZAHOUI, and Flavien TRAORE. 2018. Comparative study of Annona senegalensis (Annonaceae) and Hallea ledermannii (Rubiacaceae) effects on glycemia in rats. Journal of Complementary Medicine Research, 7 (1), 1-7. doi:10.5455/jice.20170909091946



Chicago Style

NANTI, Goore Guy Charles Gole, Semi Anthelme NENE BI, Ouga Stanislas ZAHOUI, and Flavien TRAORE. "Comparative study of Annona senegalensis (Annonaceae) and Hallea ledermannii (Rubiacaceae) effects on glycemia in rats." Journal of Complementary Medicine Research 7 (2018), 1-7. doi:10.5455/jice.20170909091946



MLA (The Modern Language Association) Style

NANTI, Goore Guy Charles Gole, Semi Anthelme NENE BI, Ouga Stanislas ZAHOUI, and Flavien TRAORE. "Comparative study of Annona senegalensis (Annonaceae) and Hallea ledermannii (Rubiacaceae) effects on glycemia in rats." Journal of Complementary Medicine Research 7.1 (2018), 1-7. Print. doi:10.5455/jice.20170909091946



APA (American Psychological Association) Style

NANTI, G. G. C. G., BI, S. A. N., ZAHOUI, O. S. & TRAORE, F. (2018) Comparative study of Annona senegalensis (Annonaceae) and Hallea ledermannii (Rubiacaceae) effects on glycemia in rats. Journal of Complementary Medicine Research, 7 (1), 1-7. doi:10.5455/jice.20170909091946





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