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Original Research 


Exploratory studies of some Mexican medicinal plants. Cardiovascular effects in rats with and without hypertension.

Gil Alfonso Magos-Guerrero, Jacinto Santiago-Meja, Omar Francisco Carrasco.

Cited by (3)

Abstract
Background: Papaveraceae Argemone mexicana L., Burseraceae Bursera simaruba (L.) Sarg., Acanthaceae Justicia spicigera Schltdl. and Selaginellaceae Selaginella lepidophylla (Hook. & Grev.) Spring., have been used in Mexican traditional medicine to treat hypertension. The objective of this study was to further characterize the cardiovascular effects of the methanol extracts of such plants. Methods: The medicinal plants were collected and taxonomically identified; the methanol extract of each explored plant were administrated to conscious and unconscious male Wistar rats with and without glucose induced hypertension. The blood pressure and heart rate were evaluated before and after the extract administration. Vascular reactivity experiments were conducted in rat aortic rings obtained from rats with and without sugar induced hypertension, a model widely used to study such effects with cardiovascular agents. Results: After oral administration in normotensive conscious rats all tested extracts decreased the heart rate, such effect was only observed in hypertensive conscious rats after the administration of B. simaruba; only A. mexicana and B. simaruba decreased the blood pressure after oral administration. All extracts administrated by intravenous injection diminished the mean arterial pressure. Dose response curves to cumulative concentrations of all the extracts promote vascular relaxation in precontracted aortas from rats with and without sugar induced hypertension. Conclusions: The present study indicated that B. simaruba is worthy of further investigation as a potential phytotherapeutic agent for treating hypertension.

Key words: Traditional mexican medicine, hypertension, Argemone mexicana, Bursera simaruba, Justicia spicigera, Selaginella lepidophylla


 
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How to Cite this Article
Pubmed Style

Gil Alfonso Magos-Guerrero, Jacinto Santiago-Meja, Omar Francisco Carrasco. Exploratory studies of some Mexican medicinal plants. Cardiovascular effects in rats with and without hypertension.. J Complement Med Res. 2017; 6(3): 274-279. doi:10.5455/jice.20170706061922


Web Style

Gil Alfonso Magos-Guerrero, Jacinto Santiago-Meja, Omar Francisco Carrasco. Exploratory studies of some Mexican medicinal plants. Cardiovascular effects in rats with and without hypertension.. http://www.jocmr.com/?mno=263459 [Access: July 16, 2019]. doi:10.5455/jice.20170706061922


AMA (American Medical Association) Style

Gil Alfonso Magos-Guerrero, Jacinto Santiago-Meja, Omar Francisco Carrasco. Exploratory studies of some Mexican medicinal plants. Cardiovascular effects in rats with and without hypertension.. J Complement Med Res. 2017; 6(3): 274-279. doi:10.5455/jice.20170706061922



Vancouver/ICMJE Style

Gil Alfonso Magos-Guerrero, Jacinto Santiago-Meja, Omar Francisco Carrasco. Exploratory studies of some Mexican medicinal plants. Cardiovascular effects in rats with and without hypertension.. J Complement Med Res. (2017), [cited July 16, 2019]; 6(3): 274-279. doi:10.5455/jice.20170706061922



Harvard Style

Gil Alfonso Magos-Guerrero, Jacinto Santiago-Meja, Omar Francisco Carrasco (2017) Exploratory studies of some Mexican medicinal plants. Cardiovascular effects in rats with and without hypertension.. J Complement Med Res, 6 (3), 274-279. doi:10.5455/jice.20170706061922



Turabian Style

Gil Alfonso Magos-Guerrero, Jacinto Santiago-Meja, Omar Francisco Carrasco. 2017. Exploratory studies of some Mexican medicinal plants. Cardiovascular effects in rats with and without hypertension.. Journal of Complementary Medicine Research, 6 (3), 274-279. doi:10.5455/jice.20170706061922



Chicago Style

Gil Alfonso Magos-Guerrero, Jacinto Santiago-Meja, Omar Francisco Carrasco. "Exploratory studies of some Mexican medicinal plants. Cardiovascular effects in rats with and without hypertension.." Journal of Complementary Medicine Research 6 (2017), 274-279. doi:10.5455/jice.20170706061922



MLA (The Modern Language Association) Style

Gil Alfonso Magos-Guerrero, Jacinto Santiago-Meja, Omar Francisco Carrasco. "Exploratory studies of some Mexican medicinal plants. Cardiovascular effects in rats with and without hypertension.." Journal of Complementary Medicine Research 6.3 (2017), 274-279. Print. doi:10.5455/jice.20170706061922



APA (American Psychological Association) Style

Gil Alfonso Magos-Guerrero, Jacinto Santiago-Meja, Omar Francisco Carrasco (2017) Exploratory studies of some Mexican medicinal plants. Cardiovascular effects in rats with and without hypertension.. Journal of Complementary Medicine Research, 6 (3), 274-279. doi:10.5455/jice.20170706061922





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