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Dietary incorporation of whey proteins and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice

Praveen Kumar Kavadi, Ramesh Pothuraju, Raj Kumar Sharma, Jayasimha Chagalamarri, Gaurav Bhakri, Aswani Mallepogu.

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Abstract
Background: The present study was planned to investigate the effectiveness of whey protein isolate (WPI) of high purity and a galactooligosaccharides (GOS) preparation on glucose homeostasis and insulin resistance under high fat diet (45.47% energy from fat) fed conditions in C57BL/6 mice. The mRNA expression of genes related to gluconeogenesis was also examined. Methods: Fasting blood glucose level, serum insulin & GLP-1 (ELISA) were measured; HOMA-IR determined in different treatment groups. mRNA expression of gluconeogenesis genes in liver and small intestine tissues analysed by qRT-PCR. Results: Dietary incorporation of WPI/GOS alone or in combination was observed to significantly resist (p<0.001) the high fat diet induced increase in blood glucose levels indicating a normalizing effect. However, no additive effect of administration of WPI and GOS in combination could be observed. The administration of WPI and GOS in combination exhibited maximum resistance (37.8%) to the rise in insulin level. Resistance to the increase in HOMA-IR was also visible on dietary incorporation of two functional ingredients. The positive effects on mRNA expression of PEPCK and glucose 6-phosphatase could be seen in liver only. Conclusion: Both types of functional components exhibited potential to improve glucose homeostasis under high fat diet fed conditions. Resistance to high fat diet induced hyperinsulinemia and HOMA-IR was also visible.

Key words: High fat diet, glucose homeostasis, insulin resistance, whey protein isolate, galactooligosaccharides.


 
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How to Cite this Article
Pubmed Style

Kavadi PK, Pothuraju R, Sharma RK, Chagalamarri J, Bhakri G, Mallepogu A. Dietary incorporation of whey proteins and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice. J Complement Med Res. 2017; 6(3): 326-332. doi:10.5455/jice.20170526091235


Web Style

Kavadi PK, Pothuraju R, Sharma RK, Chagalamarri J, Bhakri G, Mallepogu A. Dietary incorporation of whey proteins and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice. http://www.jocmr.com/?mno=238710 [Access: June 21, 2018]. doi:10.5455/jice.20170526091235


AMA (American Medical Association) Style

Kavadi PK, Pothuraju R, Sharma RK, Chagalamarri J, Bhakri G, Mallepogu A. Dietary incorporation of whey proteins and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice. J Complement Med Res. 2017; 6(3): 326-332. doi:10.5455/jice.20170526091235



Vancouver/ICMJE Style

Kavadi PK, Pothuraju R, Sharma RK, Chagalamarri J, Bhakri G, Mallepogu A. Dietary incorporation of whey proteins and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice. J Complement Med Res. (2017), [cited June 21, 2018]; 6(3): 326-332. doi:10.5455/jice.20170526091235



Harvard Style

Kavadi, P. K., Pothuraju, R., Sharma, R. K., Chagalamarri, J., Bhakri, G. & Mallepogu, A. (2017) Dietary incorporation of whey proteins and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice. J Complement Med Res, 6 (3), 326-332. doi:10.5455/jice.20170526091235



Turabian Style

Kavadi, Praveen Kumar, Ramesh Pothuraju, Raj Kumar Sharma, Jayasimha Chagalamarri, Gaurav Bhakri, and Aswani Mallepogu. 2017. Dietary incorporation of whey proteins and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice. Journal of Complementary Medicine Research, 6 (3), 326-332. doi:10.5455/jice.20170526091235



Chicago Style

Kavadi, Praveen Kumar, Ramesh Pothuraju, Raj Kumar Sharma, Jayasimha Chagalamarri, Gaurav Bhakri, and Aswani Mallepogu. "Dietary incorporation of whey proteins and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice." Journal of Complementary Medicine Research 6 (2017), 326-332. doi:10.5455/jice.20170526091235



MLA (The Modern Language Association) Style

Kavadi, Praveen Kumar, Ramesh Pothuraju, Raj Kumar Sharma, Jayasimha Chagalamarri, Gaurav Bhakri, and Aswani Mallepogu. "Dietary incorporation of whey proteins and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice." Journal of Complementary Medicine Research 6.3 (2017), 326-332. Print. doi:10.5455/jice.20170526091235



APA (American Psychological Association) Style

Kavadi, P. K., Pothuraju, R., Sharma, R. K., Chagalamarri, J., Bhakri, G. & Mallepogu, A. (2017) Dietary incorporation of whey proteins and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice. Journal of Complementary Medicine Research, 6 (3), 326-332. doi:10.5455/jice.20170526091235