E-ISSN 2577-5669
 

Original Research 


Comparative evaluation of anti-inflammatory activity of Manahshila (Realgar)

Vineet Sharma, Komal Bansal, K.R.C Reddy, Dev Nath Singh Gautam, Narendra Kumar Singh, Himanshu Rai.

Abstract
Background: Realgar popularly known as Manahshila (in Ayurveda) is an arsenic and sulphur containing mineral drug. The Manahshila is used after Shodhana (purification) for the treatment of various diseases in traditional Indian systems of medicine which also includes pain related disorders. Aim: This study is aimed to evaluate the comparative anti-inflammatory efficacy of Manahshila using in vivo models of inflammation in rats. Materials and Methods: In the present study, Shodhana of Manahshila is performed by the Bhavana (levigation) where trituration of Manahshila is done with ginger (Zingiber officinale Rosc.) juice, sesbania leaves (Sesbania grandiflora Poir.) juice, lemon (Citrus medica Linn.) juice and lime water. The anti-inflammatory activity of the Manahshila at 0.35, 0.7 and 1.4 mg/kg, p.o. was evaluated by egg albumin induced hind paw edema in rats. Results: The Ashodhita Manahshila (crude realgar) showed mortality while Shodhita Manahshila (purified with all 4 media) did not showed mortality in the treated rats up to a dose of 2,000 mg/kg. Ashodhita and Shodhita Manahshila revealed that at the dose level of 1.4 mg/kg it showed inhibition (p < 0.05) of egg albumin-induced hind paw edema. But Shodhita Manahshila showed anti-inflammatory activity at all three dose level in a dose dependent manner. The ginger juice treated Manahshila (56.60%) was found best alleviates ratís response to egg albumin induced inflammation among all group. Conclusion: The results validate its usage in the healing of inflammation and also give support to its perspective as the source of novel pain relief medicine prototype.

Key words: Inflammation; Manahshila; Organomineral; Shodhana


 
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How to Cite this Article
Pubmed Style

Sharma V, Bansal K, Reddy K, Gautam DNS, Singh NK, Rai H, . Comparative evaluation of anti-inflammatory activity of Manahshila (Realgar). J Complement Med Res. 2019; 10(1): 1-12. doi:10.5455/jcmr.20181028100040


Web Style

Sharma V, Bansal K, Reddy K, Gautam DNS, Singh NK, Rai H, . Comparative evaluation of anti-inflammatory activity of Manahshila (Realgar). http://www.jocmr.com/?mno=14566 [Access: February 15, 2020]. doi:10.5455/jcmr.20181028100040


AMA (American Medical Association) Style

Sharma V, Bansal K, Reddy K, Gautam DNS, Singh NK, Rai H, . Comparative evaluation of anti-inflammatory activity of Manahshila (Realgar). J Complement Med Res. 2019; 10(1): 1-12. doi:10.5455/jcmr.20181028100040



Vancouver/ICMJE Style

Sharma V, Bansal K, Reddy K, Gautam DNS, Singh NK, Rai H, . Comparative evaluation of anti-inflammatory activity of Manahshila (Realgar). J Complement Med Res. (2019), [cited February 15, 2020]; 10(1): 1-12. doi:10.5455/jcmr.20181028100040



Harvard Style

Sharma, V., Bansal, . K., Reddy, . K., Gautam, . D. N. S., Singh, . N. K., Rai, . H. & (2019) Comparative evaluation of anti-inflammatory activity of Manahshila (Realgar). J Complement Med Res, 10 (1), 1-12. doi:10.5455/jcmr.20181028100040



Turabian Style

Sharma, Vineet, Komal Bansal, K.R.C Reddy, Dev Nath Singh Gautam, Narendra Kumar Singh, Himanshu Rai, and . 2019. Comparative evaluation of anti-inflammatory activity of Manahshila (Realgar). Journal of Complementary Medicine Research, 10 (1), 1-12. doi:10.5455/jcmr.20181028100040



Chicago Style

Sharma, Vineet, Komal Bansal, K.R.C Reddy, Dev Nath Singh Gautam, Narendra Kumar Singh, Himanshu Rai, and . "Comparative evaluation of anti-inflammatory activity of Manahshila (Realgar)." Journal of Complementary Medicine Research 10 (2019), 1-12. doi:10.5455/jcmr.20181028100040



MLA (The Modern Language Association) Style

Sharma, Vineet, Komal Bansal, K.R.C Reddy, Dev Nath Singh Gautam, Narendra Kumar Singh, Himanshu Rai, and . "Comparative evaluation of anti-inflammatory activity of Manahshila (Realgar)." Journal of Complementary Medicine Research 10.1 (2019), 1-12. Print. doi:10.5455/jcmr.20181028100040



APA (American Psychological Association) Style

Sharma, V., Bansal, . K., Reddy, . K., Gautam, . D. N. S., Singh, . N. K., Rai, . H. & (2019) Comparative evaluation of anti-inflammatory activity of Manahshila (Realgar). Journal of Complementary Medicine Research, 10 (1), 1-12. doi:10.5455/jcmr.20181028100040