E-ISSN 2577-5669
 

Original Research 


Toxicological and Reversibility Studies of Bryophyllum pinnatum Leaf Extract on Biochemical, Peroxidation and Histopathologic Parameters in Rodents

Omoniyi K. Yemitan, Akinyemi O. Akinsuyi, Peter I. Jewo, Jamiu A. Oguntola, Sunday O. Olayemi.

Abstract
Aim: The aqueous leaf extract of B. pinnatum (BP) is effective as herbal medicine for hypertension, diabetes and convulsions, for which there has not been reliable subchronic toxicity data. This study aimed to study possible health effects of sub-chronic use of BP, as a predictor of long-term use in humans.
Methods: Acute 24h oral (in mice) and 90 day-subchronic toxicity (in rats) tests were conducted as predictors for human outcome. Following 90 days, and 21 days reversibility tests, biochemical- ALP, ALT and AST, LDH, direct bilirubin, uric acid and creatinine were measured; oxidative stress- CAT, SOD), MDA; and histopathologic parameters were determined. No mortality was recorded up to 5g/kg of BP in acute toxicity test. After 90 days, 1000 mg/kg BP, caused significant, but reversible increases in all ALP, AST, ALT, LDH, uric acid, and creatinine.
Results: At 100 & 1000 mg/kg of BP, the MDA was significantly elevated for kidney, heart, lungs and spleen; but at 1000 mg/kg, BP produced significant reduction of CAT and SOD; and elevation of MDA for all organs. These effects on CAT, SOD and MDA, except the lungs at 1000 mg/kg and testes at 100 mg/kg and 1000 mg/kg, were reversed. At 1000 mg/kg BP caused some observable changes in the kidneys and liver of few of the rats, irreversible pathologic changes were observed in the testis.
Conclusion: These findings suggest that vital organs toxicities could occur during long-term use of BP, especially for irreversible pathologic changes in the testis.

Key words: Bryophyllum pinnatum, Peroxidation, Testis, Histopathology, Subchronic toxicity


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Omoniyi K. Yemitan
Articles by Akinyemi O. Akinsuyi
Articles by Peter I. Jewo
Articles by Jamiu A. Oguntola
Articles by Sunday O. Olayemi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Omoniyi K. Yemitan, Akinyemi O. Akinsuyi, Peter I. Jewo, Jamiu A. Oguntola, Sunday O. Olayemi. Toxicological and Reversibility Studies of Bryophyllum pinnatum Leaf Extract on Biochemical, Peroxidation and Histopathologic Parameters in Rodents. J Complement Med Res. 2020; 11(1): 95-108. doi:10.5455/jcmr.2020.11.01.11


Web Style

Omoniyi K. Yemitan, Akinyemi O. Akinsuyi, Peter I. Jewo, Jamiu A. Oguntola, Sunday O. Olayemi. Toxicological and Reversibility Studies of Bryophyllum pinnatum Leaf Extract on Biochemical, Peroxidation and Histopathologic Parameters in Rodents. http://www.jocmr.com/?mno=13900 [Access: July 03, 2020]. doi:10.5455/jcmr.2020.11.01.11


AMA (American Medical Association) Style

Omoniyi K. Yemitan, Akinyemi O. Akinsuyi, Peter I. Jewo, Jamiu A. Oguntola, Sunday O. Olayemi. Toxicological and Reversibility Studies of Bryophyllum pinnatum Leaf Extract on Biochemical, Peroxidation and Histopathologic Parameters in Rodents. J Complement Med Res. 2020; 11(1): 95-108. doi:10.5455/jcmr.2020.11.01.11



Vancouver/ICMJE Style

Omoniyi K. Yemitan, Akinyemi O. Akinsuyi, Peter I. Jewo, Jamiu A. Oguntola, Sunday O. Olayemi. Toxicological and Reversibility Studies of Bryophyllum pinnatum Leaf Extract on Biochemical, Peroxidation and Histopathologic Parameters in Rodents. J Complement Med Res. (2020), [cited July 03, 2020]; 11(1): 95-108. doi:10.5455/jcmr.2020.11.01.11



Harvard Style

Omoniyi K. Yemitan, Akinyemi O. Akinsuyi, Peter I. Jewo, Jamiu A. Oguntola, Sunday O. Olayemi (2020) Toxicological and Reversibility Studies of Bryophyllum pinnatum Leaf Extract on Biochemical, Peroxidation and Histopathologic Parameters in Rodents. J Complement Med Res, 11 (1), 95-108. doi:10.5455/jcmr.2020.11.01.11



Turabian Style

Omoniyi K. Yemitan, Akinyemi O. Akinsuyi, Peter I. Jewo, Jamiu A. Oguntola, Sunday O. Olayemi. 2020. Toxicological and Reversibility Studies of Bryophyllum pinnatum Leaf Extract on Biochemical, Peroxidation and Histopathologic Parameters in Rodents. Journal of Complementary Medicine Research, 11 (1), 95-108. doi:10.5455/jcmr.2020.11.01.11



Chicago Style

Omoniyi K. Yemitan, Akinyemi O. Akinsuyi, Peter I. Jewo, Jamiu A. Oguntola, Sunday O. Olayemi. "Toxicological and Reversibility Studies of Bryophyllum pinnatum Leaf Extract on Biochemical, Peroxidation and Histopathologic Parameters in Rodents." Journal of Complementary Medicine Research 11 (2020), 95-108. doi:10.5455/jcmr.2020.11.01.11



MLA (The Modern Language Association) Style

Omoniyi K. Yemitan, Akinyemi O. Akinsuyi, Peter I. Jewo, Jamiu A. Oguntola, Sunday O. Olayemi. "Toxicological and Reversibility Studies of Bryophyllum pinnatum Leaf Extract on Biochemical, Peroxidation and Histopathologic Parameters in Rodents." Journal of Complementary Medicine Research 11.1 (2020), 95-108. Print. doi:10.5455/jcmr.2020.11.01.11



APA (American Psychological Association) Style

Omoniyi K. Yemitan, Akinyemi O. Akinsuyi, Peter I. Jewo, Jamiu A. Oguntola, Sunday O. Olayemi (2020) Toxicological and Reversibility Studies of Bryophyllum pinnatum Leaf Extract on Biochemical, Peroxidation and Histopathologic Parameters in Rodents. Journal of Complementary Medicine Research, 11 (1), 95-108. doi:10.5455/jcmr.2020.11.01.11